Background. Topical agents can be unpleasant due to long-termtherapies in patients with moderate to severe seborrheic dermatitis.\nSystemic antifungal therapy is another alternative in treatment. Aim. This study was conducted to compare the efficacy of oral\nfluconazole and terbinafine in the treatment of moderate to severe seborrheic dermatitis. Methods. 64 patients with moderate to\nsevere seborrheic dermatitis (SD) were enrolled in a randomized, parallel-group study. One study group took terbinafine 250mg\ndaily (n = 32) and the other one fluconazole 300mg (n = 32) weekly for four weeks. Seborrheic dermatitis area severity index\n(SDASI) and the intensity of itching were calculated before, at the end of treatment, and two weeks after treatment. Results. Both\ndrugs significantly reduced the severity of seborrheic dermatitis (P < 0.001). Multivariate linear regression revealed that efficacy\nof terbinafine is more than fluconazole (P < 0.01, 95% CI (0.63ââ?¬â??4.7)). Moreover, each index of SD severity reduced 0.9 times after\ntreatment. (P < 0.002, 95% CI (0.8ââ?¬â??1.02)). The itching rate significantly diminished (P < 0.001); however, there was no difference\nbetween these two drugs statistically. Conclusions. Both systemic antifungal therapies may reduce the severity index of SD.However,\nterbinafine showed more reduction in the intensity of the disease. In other words, the more the primary intensity of the disease is,\nthe more its reduction will be.This trial is resgistered with 201102205871N1.
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